Your Guide to Finding the Best Psychiatrist in Los Angeles

Metabolic psychiatry is an emerging field that examines how metabolic dysfunction (insulin resistance, mitochondrial problems, and chronic inflammation) affects brain function.Rather than treating symptoms alone, it looks at the metabolic factors that may underlie conditions such as depression, bipolar disorder, and schizophrenia. The interest is strongest in complex mental illness, where standard treatment often falls short and where physical and psychiatric problems tend to travel together. This article explains the science behind the field, the therapies it uses, the evidence so far, and who researchers think it may help, along with the honest limits of what is still an early area of study.

What Is Metabolic Psychiatry?

Metabolic psychiatry views serious mental illnesses not solely as chemical imbalances or psychological phenomena, but as conditions also connected to disruptions in brain energy metabolism, inflammation, and cellular health. It does not discard the standard understanding of psychiatric illness. It adds a layer, asking whether the way the brain produces and uses energy is part of the picture.

‍

The term was introduced in 2015 by Dr. Shebani Sethi, who founded the first academic metabolic psychiatry clinic and research program at Stanford University after noticing how often her patients with treatment-resistant psychiatric conditions also had metabolic problems. The approach builds on more than a century of ketogenic-therapy research in neurology, where the ketogenic diet has long been used to treat drug-resistant epilepsy. Metabolic psychiatry is still emerging, and reputable clinicians frame it as a promising area of research rather than a finished or proven model of care.

The Link Between Metabolism and Mental Health

The brain is an energy-hungry organ. It makes up about 2% of body weight but uses roughly 20% of the body's energy, and it depends on a steady fuel supply to function. When metabolism breaks down, through insulin resistance, unstable blood sugar, or chronic inflammation, the brain can struggle to access the energy it needs, and researchers believe this may contribute to psychiatric symptoms.

‍

The connection runs in both directions. Roughly a third of people with schizophrenia or bipolar disorder also have metabolic syndrome, a cluster of conditions including high blood sugar, high blood pressure, and abnormal cholesterol (Vancampfort et al., World Psychiatry, 2015). People living with serious mental illness carry roughly 1.5 to 2 times the risk of metabolic syndrome and type 2 diabetes compared with the general population, an elevation driven partly by the illness, partly by medication side effects, and partly by shared biology. This is an association, not proven causation. But it is strong and consistent enough that the field takes it seriously.

How Does Metabolic Psychiatry Work?

The central idea, articulated most fully in Dr. Chris Palmer's Brain Energy theory, is that many mental disorders may be, in part, metabolic disorders of the brain. Palmer, a psychiatrist at McLean Hospital and Harvard Medical School, places mitochondria, the structures that produce energy inside cells, at the center of the model.

‍

Here is the mechanism in plain terms. When brain cells cannot get or use energy properly, often because insulin resistance blocks glucose from entering cells, it can trigger a cascade: mitochondrial dysfunction, oxidative stress, and inflammation. That cascade can disrupt neurotransmitters and interfere with the brain regions that regulate mood, thinking, and perception. Metabolic therapies aim to work upstream of that cascade, restoring the brain's energy supply and lowering inflammation rather than only adjusting neurotransmitters downstream. The theory is compelling and biologically plausible, and it remains a theory under active investigation, not settled fact.

Metabolic Therapies Used in Metabolic Psychiatry

One point clinicians in this field stress is that the toolkit is broader than a single diet. Metabolic health is shaped by many inputs, and a metabolic approach typically addresses several at once:

‍

• Ketogenic therapy: the clinically supervised use of a well-formulated ketogenic diet to shift the brain toward ketones as fuel (the cornerstone intervention, covered below).
• Nutritional changes: reducing sugar, ultra-processed foods, and refined carbohydrates.
• Intermittent fasting: may improve insulin sensitivity and reduce inflammation.
• Exercise: improves insulin sensitivity, supports mitochondrial function, and reduces inflammation.
• Sleep optimization: poor sleep worsens insulin resistance and mitochondrial function.
• Stress management: chronic stress raises cortisol, which disrupts glucose regulation.
• Removing metabolic stressors: reducing smoking, excess alcohol, and sedentary time.

‍

Several of these are ordinary lifestyle measures. What is different in metabolic psychiatry is the reason behind them: they are used deliberately to improve brain energy metabolism, tracked with lab data, and coordinated with conventional psychiatric care.

Ketogenic Therapy: The Cornerstone Intervention

The ketogenic diet was developed more than a century ago to treat drug-resistant epilepsy, and that long neurological track record is part of why it draws the most research attention in psychiatry. A ketogenic diet is very low in carbohydrates, which shifts the body into nutritional ketosis: the liver begins converting fat into ketones, an alternate fuel the brain can use when insulin resistance limits its access to glucose.

‍

Beyond supplying fuel, ketones may reduce inflammation, lower oxidative stress, support mitochondrial function, and help rebalance neurotransmitters. Those are plausible mechanisms, and they are still being studied.

‍

The most important thing to understand is that ketogenic therapy, as used in this field, is a clinical intervention, not a do-it-yourself diet. It is supervised by clinicians, monitored with regular lab work, and integrated with a person's other treatment. It is not presented by responsible practitioners as a cure, and it is not a replacement for medication. Any change to psychiatric medication belongs in the hands of a treating clinician who knows the person's history.

What Does a Metabolic Psychiatry Evaluation Involve?

A metabolic approach usually starts with screening that goes beyond a standard psychiatric assessment, adding blood work to build a picture of a person's metabolic health. That panel commonly includes:

‍

• Fasting glucose and insulin, plus hemoglobin A1C, to assess blood sugar regulation
• A lipid panel: triglycerides, HDL, and LDL
• A thyroid panel
• Inflammatory markers such as C-reactive protein (CRP)
• Key vitamin and mineral levels, including B12, folate, magnesium, and omega-3s

‍

The point of this data is not to produce a standalone diagnosis. It is to identify metabolic factors a clinician can address alongside conventional psychiatric care, and to establish a baseline that lab work can track over time.

Metabolic Psychiatry vs. Standard Psychiatry

Metabolic psychiatry is best understood as a complement to standard psychiatric care, not a replacement for it.

‍

‍

The honest framing matters. Standard psychiatry, medication and therapy, remains the evidence-based foundation. Metabolic psychiatry adds a layer that some clinicians and researchers believe addresses root-cause biology, and it works best woven into conventional treatment rather than substituted for it.

How Metabolic Psychiatry Fits Within Precision Psychiatry

Metabolic psychiatry is often considered part of the broader precision psychiatry movement, which tailors treatment to each person's unique biology rather than applying population averages. Both reject one-size-fits-all, trial-and-error prescribing in favor of care informed by an individual's own data. Metabolic screening is one example of that data. Precision psychiatry is the larger shift, and it is the philosophy behind research programs like the Amae Institute, which studies how to match people living with complex conditions to more effective, individualized care.

Who Might Benefit from Metabolic Psychiatry?

Research and clinical interest are concentrated in complex mental health conditions, the situations where standard treatment most often falls short. The strongest focus so far has been on:

‍

• Bipolar disorder and schizophrenia, where metabolic syndrome is common and where the first clinical trials have concentrated. People navigating a recent diagnosis can learn more about bipolar disorder treatment and how it is managed within an integrated model.
• Treatment-resistant depression, where conventional approaches have not produced adequate relief.
• People with co-occurring metabolic conditions such as insulin resistance, type 2 diabetes, or obesity.
• People who have not responded well to, or cannot tolerate, standard treatments.

‍

Two caveats belong with every one of these. The field is emerging, so the evidence is still being built. And metabolic therapies are used alongside, not instead of, conventional psychiatric care, always under medical supervision. Whether a metabolic approach is appropriate for any individual is a clinical judgment, made by a clinician who knows that person's full history.

The Evidence So Far

The evidence is a mix of a strong foundation and promising but early results. Ketogenic therapy has more than a century of established use in epilepsy, which gives the underlying biology real credibility. For psychiatric conditions specifically, the picture is younger.

‍

In 2024, a Stanford pilot trial led by Dr. Sethi followed more than 20 adults with bipolar disorder or schizophrenia who also had metabolic abnormalities through a four-month ketogenic intervention. It was the first U.S. clinical trial of a ketogenic diet for serious mental illness since 1965. Most participants showed improvement in their psychiatric symptoms, reduced medication-related weight gain, and better metabolic markers; by the study's end, none still met the criteria for metabolic syndrome (Sethi et al., Psychiatry Research, 2024). It was a small, single-arm pilot, not a randomized controlled trial, so the results are encouraging rather than definitive.

‍

Alongside trials like this, case series and clinical reports describe stabilized mood and, in some cases, reduced reliance on medication under supervision. Larger, more rigorous randomized trials are now underway (Nature Mental Health, 2026). The honest summary: a solid mechanistic foundation, genuinely promising early psychiatric results, and a field that still needs bigger and better-controlled studies before anyone can call it established.

A Whole-Person Approach at Amae Health

The logic underneath metabolic psychiatry, that physical and mental health are not separate systems, is the same logic behind integrated care. At Amae Health, primary care physicians and registered dietitians are part of the psychiatric care team, so physical health, nutrition, sleep, and metabolic comorbidities are treated alongside mental health rather than as an afterthought. That is not the same as offering a specific metabolic-psychiatry program, but it reflects the same whole-person, precision-oriented conviction: complex conditions deserve care that looks at the whole biology of a person.

‍

If you or someone you love is living with a complex mental health condition, our care model and resources for patients and families explain how integrated treatment works. To ask about care, reach out to our team.

‍

If you are in crisis or thinking about suicide, call or text the 988 Suicide and Crisis Lifeline at 988 for free, confidential support, available 24/7.

Frequently Asked Questions

What is metabolic psychiatry?

Metabolic psychiatry is an emerging field that addresses metabolic dysfunction, such as insulin resistance, mitochondrial problems, and inflammation, that may affect brain function and mental health. It targets underlying metabolic factors alongside, not instead of, conventional psychiatric care.

‍

How does metabolic psychiatry work?

The brain depends on a steady energy supply. When metabolism is disrupted, often through insulin resistance that keeps cells from using glucose, the brain can struggle to access fuel, which researchers believe may worsen psychiatric symptoms. Metabolic therapies aim to restore that brain energy and reduce inflammation, working upstream of the neurotransmitter changes that standard treatment targets.

‍

What is ketogenic therapy for mental health?

It is the clinically supervised use of a well-formulated ketogenic diet to shift the brain toward ketones as fuel. Originally developed for epilepsy, it is the most-studied metabolic therapy for serious mental illness. It is used under medical supervision with regular lab monitoring, not as a do-it-yourself diet.

‍

Is metabolic psychiatry evidence-based?

Ketogenic therapy has strong evidence in epilepsy. For psychiatric conditions, the evidence is emerging: promising pilot studies and the early stages of larger trials, but still preliminary. It is used alongside conventional care, not in place of it.

‍

Can metabolic psychiatry replace medication?

No. It is designed to complement conventional psychiatric care, not replace it. Some people reduce their reliance on medication under close medical supervision, but changing psychiatric medication should never be attempted alone.

‍

Who is metabolic psychiatry best for?

Research has focused most on bipolar disorder, schizophrenia, and treatment-resistant depression, especially alongside co-occurring metabolic conditions. A clinician who knows the person's history determines whether a metabolic approach is appropriate. Support is available, and no one should navigate a serious condition alone.

‍

Citations

1. Vancampfort D, Stubbs B, Mitchell AJ, et al. "Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis." World Psychiatry, 2015. PubMed 26407790. Tier 1 (peer-reviewed meta-analysis).
2. Sethi S, Wakeham D, Ketter T, et al. "Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bipolar and Schizophrenia: A Pilot Trial." Psychiatry Research, 2024. PubMed 38547601. Tier 1 (peer-reviewed pilot trial).
3. "Metabolic psychiatry targeting metabolic dysregulation in mental health." Nature Mental Health, 2026. nature.com. Tier 1 (peer-reviewed review).

‍

Further reading (external resources): Stanford Metabolic Psychiatry (Dr. Shebani Sethi); Metabolic Mind (Baszucki Group).

‍

We often think of posture as a physical habit - but it’s also a mirror of your inner world. The connection between posture and mental health runs deeper than you might expect, subtly influencing mood, focus, and emotional regulation.

This article unpacks what science says about posture’s psychological effects - and how small physical shifts might support bigger emotional change. It’s not a fix-all. But it’s a place to start noticing.

Why Your Posture Says More Than You Think

How are you sitting right now? Shoulders slumped? Head forward? Spine curved? These small physical habits may seem minor, but your posture affects more than just how you look - it’s deeply connected to how you feel and think.

What we often consider simply "bad sitting habits" can become silent signals of emotional strain. Over time, the body’s default position (especially one of collapse or tension) begins to shape the way we process stress, respond to challenges, and regulate our emotions.

Poor posture can influence:

• Breathing patterns and oxygen flow
• Muscle tension and chronic pain
• Fatigue and low energy
• Confidence and self-perception
• Emotional states like anxiety or sadness

In contrast, sitting up straight with good posture helps improve focus, circulation, and overall mood. The relationship between posture and mental health isn’t just behavioral - it’s biological. As we’ll explore in the next sections, better posture isn’t only about avoiding back pain; it’s a foundation for better emotional balance and long-term mental health.

The Science Behind Posture and Mental Health

In one study published in Health Psychology, participants who sat upright during a stressful task reported feeling more alert, confident, and in control compared to those in a slouched position. Their body language didn’t just reflect their emotional state - it shaped it. This offers a clearer picture of the relationship between posture and anxiety, showing that how we sit and move can influence both short-term reactions and long-term emotional patterns.

Below, we explore how posture connects with mood, anxiety, and symptoms of depression - and why these physical cues matter more than we often realize.

How Body Position Shapes Your Mood

Maintaining an upright posture supports a more open, engaged state - both physically and emotionally. In the study, participants who sat up straight while delivering a stressful speech reported greater self-esteem and used more balanced, confident language. This highlights how posture can shape our internal state, not just reflect it.

Researchers have also found similar effects in "power pose" research, suggesting that expansive postures can influence hormonal activity and emotional readiness.

• Key takeaway: Upright posture can reinforce emotional stability and support a more confident mindset.

Posture, Anxiety, and Cognitive Bias

Anxiety often starts in the body. A slouched, compressed posture can restrict breathing and heighten physical tension - sending the brain a subtle message that danger is near. This connection between posture and anxiety is part of a self-reinforcing loop, where the body shapes thought patterns and vice versa.

While posture alone doesn’t treat anxiety, improving it can interrupt this feedback loop and support other tools like mental health counseling.

• Key takeaway: Correcting posture helps reduce the body’s stress signals that fuel anxious thinking.

Depression, Slouching, and Learned Helplessness

Depression is often expressed through the body - in reduced movement, slumped shoulders, and a lowered gaze. Participants assigned to slouched posture in the study reported more negative thoughts and used language tied to sadness and helplessness.

Though good posture won’t reverse depression on its own, it can help shift physical cues that reinforce low mood, especially when paired with supportive care or treatment.

• Key takeaway: Collapsed posture may sustain depressive patterns, while upright posture can gently support emotional engagement.

How Poor Posture Affects Your Physical Health

The Silent Strain on Your Spine and Organs

Poor posture leads to subtle yet consistent pressure on your musculoskeletal system. Muscles must overcompensate to hold you upright, while organs become compressed - reducing efficiency and function.

Here’s how posture affects different systems:

When we talk about the connection between posture and anxiety, these physical consequences are a central part of the story.

Energy, Focus, and Breathing

The way you sit and move also affects cognitive and physical performance. Slouching limits lung capacity, restricts oxygen intake, and increases muscle fatigue - all of which can reduce your ability to stay alert and focused.

Poor posture can lead to:

• Shallow breathing, which lowers oxygen delivery to the brain
• Neck and jaw tension, contributing to headaches and distraction
• Increased fatigue, as muscles work harder to stabilize the body
• Reduced circulation, which affects energy and temperature regulation
• Mental fog, often related to poor alignment and decreased airflow

Improving posture is one of the simplest ways to support clearer thinking, better energy, and overall posture and health outcomes - without requiring a major lifestyle overhaul.

What Good Posture Does for Your Brain and Body

Boosts Confidence and Emotional Stability

How we hold our bodies influences how we feel about ourselves. Standing or sitting tall helps create a sense of groundedness - a message your body sends to your brain. This physical alignment promotes greater confidence, improved self-regulation, and more balanced emotional reactions.

In social or professional settings, an upright posture also communicates calm and engagement. Over time, practicing better posture can shift self-perception, reinforcing a stronger internal narrative. This link between posture and health isn’t abstract - it’s something your nervous system registers with every movement.

Improves Physical Efficiency and Reduces Fatigue

Proper alignment reduces strain on the muscles that support your spine, letting your body do more with less effort. Here’s how posture influences performance:

When your posture works with your body you conserve energy and stay sharper throughout the day. That’s how posture and health stay connected long-term.

Supports Long-Term Mental Clarity

Better posture supports brain function by improving how the body breathes and moves. Here’s why alignment matters for your focus:

• More oxygen to the brain improves alertness and reduces brain fog during the day.
• Fewer physical distractions help minimize cognitive overload and support sustained attention.
• Reduced muscle fatigue allows you to maintain focus for longer periods without discomfort.
• Better nervous system balance promotes a calmer emotional baseline and greater mental flexibility.

When your body feels stable and open, your mind has more bandwidth. While posture won’t replace rest or therapy, it helps create the conditions for clearer thinking and more consistent mental performance.

Posture Habits That Actually Work

Posture Checkpoints in Real Life

Forget posture tips that only work in ideal conditions. Instead, build awareness where it counts:

• In the car: Adjust your seat and mirrors so you’re prompted to sit tall without leaning forward.
• On video calls: Keep your screen at eye level, feet grounded - your back slumps when you're half-engaged.
• During scrolling breaks: Whether on the couch or in bed, notice if your head is jutting forward or your spine is collapsing.
• At the desk: Set a reminder to uncross your legs, pull your shoulders back, and realign every hour.
• While cooking or doing chores: Check if you're locking your knees or leaning your weight onto one hip.
• When feeling overwhelmed: Anxiety often starts with your breath and chest. Open the ribcage, exhale slowly - posture and anxiety are more linked here than you think.
• Before sleep: Place a pillow under your knees (back sleepers) or between them (side sleepers) to reduce spinal tension overnight.

These posture "checkpoints" help bring your attention back - not to perfection, but to presence. That’s where posture and health start to shift in real life.

Building Core Strength Without a Gym

Improving posture isn’t about planks or fancy routines. It’s about waking up underused muscles - especially when you’re sitting.

Try these:

• Gently engage your lower abdomen when waiting in line or brushing your teeth.
• Lift through the crown of your head during slow walks or breaks.
• Check in with your breath: Are your ribs moving freely, or is your chest collapsed?

These small actions retrain the core muscles that hold your spine - no gym required. Over time, they support better posture, reduce strain, and improve both mental health and stamina.

Ergonomics That Make a Real Difference

Not all posture gear delivers. Some tools help, others just clutter your desk and most often simple adjustments to your setup tend to have the biggest impact on posture and health. Here’s a quick breakdown:

Beyond Posture: Dealing With Deeper Mental Health Issues

There’s a point where posture correction meets its limits. If anxiety, low mood, or exhaustion persist - even with better habits - the cause may lie deeper. It’s not just about how you sit, but what sits underneath. Conditions like depression, anxiety disorders, or trauma responses can shape posture from within, not the other way around.

That’s where therapy comes in. For many, the loop between posture and anxiety becomes automatic - slouching triggers stress, which deepens emotional discomfort. Somatic approaches, CBT, and trauma-informed care help reconnect the mind and body - especially in people with co-occurring disorders and dual diagnosis, where emotional and physical symptoms are deeply linked.

Final Thought: Straighten Your Spine, Shift Your Mind

Your posture reflects more than muscle memory - it mirrors your emotional state. Sitting upright won’t resolve chronic anxiety or low mood, but it can be the first clue that something deeper is asking for attention.

If emotional strain keeps pulling you down, physically or mentally, it might be time to address what’s underneath. At Amae Health, we support people facing anxiety, depression, and burnout with care that treats the root, not just the surface.

You deserve support that honors both mind and body. Contact our specialists when you’re ready.

‍

f you are comparing TMS, ketamine, and Spravato for depression, you have probably reached the point where standard antidepressants have not done enough. All three are evidence-based options for treatment-resistant depression, and beyond that they have little in common. TMS is a course of magnetic stimulation delivered while you sit awake in a chair. Ketamine is an anesthetic given by IV, used off-label for depression. Spravato is a nasal spray made from esketamine, one of the two mirror-image forms that make up ketamine, with its own FDA approval and its own rulebook.

‍

None of the three is universally better. They differ in mechanism, speed, setting, and monitoring, and the right one depends on your clinical history and how you respond. Treatment-resistant depression generally means depression that has not adequately improved after at least two antidepressants taken at a proper dose for long enough, and that is the group where all three are most often used.

What Is TMS?

Transcranial magnetic stimulation uses a coil placed against the scalp to deliver focused magnetic pulses to the left dorsolateral prefrontal cortex, a region involved in mood regulation. The FDA first cleared TMS for major depressive disorder in 2008, according to the National Institute of Mental Health. It is delivered in an office, with no anesthesia and no medication.

‍

Our standard TMS course runs 20 to 30 daily sessions over four to six weeks, each 30 to 40 minutes long. You stay awake throughout and drive yourself home afterward. In real-world outcome data from 42 U.S. practices, more than half of patients with medication-resistant depression responded to a standard course, and more than a third reached remission.

What Is Ketamine Therapy?

Ketamine has been an FDA-approved anesthetic since 1970. Its use for depression is off-label: prescribed for a purpose the FDA has not formally approved, which is legal and common in medicine but leaves the safeguards less standardized. It is usually given as an IV infusion in a monitored clinic, as a series of sessions over a few weeks.

‍

Ketamine blocks the NMDA receptor, a glutamate receptor, rather than acting on serotonin like standard antidepressants, and that difference is thought to explain its speed. In a landmark 2006 trial, 18 people with treatment-resistant depression received a single infusion of 0.5 mg/kg, and their symptoms improved significantly within 110 minutes. By the next day, 71% had responded and 29% were in remission. One week later, 35% still met the response threshold. Rapid, real, and often short-lived.

‍

The catch is in the monitoring. Ketamine causes dissociation, a sense of detachment from your body or surroundings, plus sedation and blood pressure rises during and after the infusion, so you are observed until those effects pass and cannot drive that day. In a 2017 consensus statement in JAMA Psychiatry, an American Psychiatric Association task force found the evidence for rapid antidepressant effects convincing but the studies small, the longer-term efficacy data lacking, and the safety data on repeated dosing limited.

What Is Spravato (Esketamine)?

Ketamine is a mixture of two mirror-image molecules. Spravato is esketamine, one of those two, delivered as a nasal spray. Unlike IV ketamine, it has FDA approval for depression. The original approval came in March 2019 for treatment-resistant depression alongside an oral antidepressant, a second indication followed for adults with major depressive disorder and acute suicidal thoughts or behavior, and in January 2025 the FDA approved Spravato as a standalone monotherapy for treatment-resistant depression, with no oral antidepressant required, per the current prescribing information.

‍

That approval comes with a rulebook. Spravato can only be given at a setting certified under a Risk Evaluation and Mitigation Strategy (REMS) program: you take the spray under supervision, you are monitored for at least two hours before an assessment clears you to leave, and you cannot drive until the next day after a restful sleep. Its label carries a boxed warning for sedation, dissociation, respiratory depression, abuse and misuse, and suicidal thoughts and behaviors in younger patients.

‍

So is Spravato the same as ketamine? Related, not identical: same molecular family, same receptor, similar rapid onset and dissociative effects, but a different route, a formal FDA indication, and mandatory monitoring rules that off-label ketamine does not carry. For most people comparing TMS vs Spravato, those rules and insurance coverage are the practical differences that matter.

TMS vs Ketamine vs Spravato: Side-by-Side Comparison

Onset and Duration of Effect

Speed is the clearest dividing line. TMS builds gradually, and many people do not notice a clear change until the second or third week or later. Ketamine and Spravato can shift symptoms within hours to days.

‍

Speed and staying power are different things. Ketamine's effect after a single infusion often fades within a week or two, which is why it is given as a series with maintenance dosing. Spravato starts at twice a week and tapers, with the need for continued treatment reassessed along the way. Research on durability is still developing for all three, and none should be described as permanent.

Side Effects and Safety Considerations

TMS side effects are local and short-lived: scalp discomfort where the coil sits, headache, and sometimes brief lightheadedness or facial muscle twitching during the pulses. These usually settle within the first week, and because nothing enters the bloodstream there is no weight gain, sexual dysfunction, or sedation. Seizure is the one serious risk, exceedingly rare, and TMS is not used in people with a seizure history, metal in the head, or implanted electronic devices.

‍

Ketamine and Spravato share a different profile. The most common reactions to Spravato in trials were dissociation, dizziness, nausea, sedation, vertigo, numbness, anxiety, lethargy, increased blood pressure, vomiting, feeling drunk, and headache. Those effects peak in the hours after dosing, which is what the monitoring window is for, and both drugs carry a potential for misuse that shapes who is a candidate. Each option has its own screening, and a contraindication to one does not rule out the others.

Cost and Insurance

For TMS, most commercial insurers cover treatment for major depressive disorder once eligibility criteria are met, typically a confirmed diagnosis and documented antidepressant trials without adequate relief. Prior authorization is standard. For TMS we take all commercial insurance plans, cash pay is available, and authorization is something our intake team manages for you.

‍

Spravato is more commonly covered than off-label ketamine because it has an FDA indication insurers can write criteria around, though prior authorization and documentation of failed antidepressant trials are typically required. Ketamine infusion coverage varies widely, and many clinics are self-pay. Published cost estimates vary so much by dose, frequency, and insurance status that a single dollar figure would mislead; ask each provider and your insurer directly.

Can These Treatments Be Combined?

Sometimes, and the research is early. A 2024 systematic review found six published studies on combining TMS with ketamine, mostly case reports plus one retrospective review and one small pilot, and reported substantial and sustained improvement with generally mild side effects. The authors also said the designs were too varied and the samples too small for firm conclusions, and called for randomized trials.

‍

In practice, TMS and Spravato are sometimes used one after the other. Combining any of these is a clinical judgment a psychiatrist makes from your history, not a general recommendation, and the more common pattern is to use one, assess the response, then decide.

Choosing Between Them: What Influences the Decision

A psychiatrist weighing these options usually works through a short list:

‍

• Treatment history. Which antidepressants, at what doses, for how long, and whether psychotherapy has been tried.
• How urgently relief is needed. When symptoms are severe or suicidal thoughts are present, a faster-acting option may take priority, alongside care for suicidal thoughts.
• Tolerance for the experience. Dissociation and a two-hour monitored window, versus a daily half-hour appointment for several weeks with no drug effects.
• Practical constraints. Whether you can get to daily sessions, whether someone can drive you home after Spravato or ketamine, and what your insurance will authorize.
• Health factors. Seizure history, metal implants, blood pressure, and any history of substance misuse each rule options in or out.
• What else is in place. Any of the three works better inside ongoing psychiatric care and therapy than as a standalone fix.

Making the Decision With an Integrated Care Team

TMS, ketamine, and Spravato are tools, and tools do their best work inside a plan: a psychiatrist who knows your history, a therapist working alongside the biological treatment, and a team that notices when the plan needs to change.

‍

That is how we work. At Amae, our one-team care model combines psychiatry, therapy, primary care, and peer support, and TMS and Spravato are available through our Los Angeles and Bay Area clinics as part of that care. If you have been through the antidepressant cycle and want a clear, unhurried look at what comes next, talk with an Amae psychiatrist about your options. If you are in crisis or thinking about suicide, call or text 988 now.

Frequently Asked Questions

What is the difference between TMS and ketamine for depression?

TMS stimulates the brain with magnetic pulses over a course of daily outpatient sessions, with no drug, no sedation, and no monitoring afterward. Ketamine is a medication that acts on NMDA receptors, given by infusion or, as esketamine, by nasal spray, with monitored sedation and dissociation and often faster but shorter-lived effects.

Is Spravato the same as ketamine?

Related but not identical. Spravato is esketamine, the S-enantiomer of the ketamine molecule, delivered as an FDA-approved nasal spray under a required monitoring program. Ketamine infusions use the full ketamine compound and are prescribed off-label for depression, without an FDA indication for that use.

Is Spravato only approved with an antidepressant?

Not anymore. The original 2019 approval was for use alongside an oral antidepressant, and in January 2025 the FDA also approved Spravato as a standalone monotherapy for adults with treatment-resistant depression. Whether it is used alone or with an antidepressant is a decision your psychiatrist makes based on your situation.

Which works faster, TMS or Spravato?

Spravato. Esketamine and ketamine can produce symptom change within hours to days, while TMS builds gradually across a four-to-six-week course. Faster onset does not mean more durable improvement, and both durability and side effects belong in the comparison.

Can TMS and Spravato be used together?

Sometimes, as a clinical decision made with a psychiatrist based on your individual history. Both can be part of a broader treatment-resistant depression plan alongside medication and therapy, and the evidence on combining them is still early.

Is ketamine or Spravato covered by insurance?

Spravato is more commonly covered, because it has an FDA indication insurers can build criteria around, though prior authorization and proof of failed antidepressant trials are usually required. Coverage for off-label ketamine infusions varies widely and is often self-pay. Confirm with the provider and your insurer before starting.

‍

Citations

1. National Institute of Mental Health. Brain Stimulation Therapies. https://www.nimh.nih.gov/health/topics/brain-stimulation-therapies/brain-stimulation-therapies (Tier 2)
2. Carpenter LL, Janicak PG, Aaronson ST, et al. Transcranial magnetic stimulation (TMS) for major depression: a multisite, naturalistic, observational study of acute treatment outcomes in clinical practice. Depression and Anxiety. 2012. https://pubmed.ncbi.nlm.nih.gov/22689344/ (Tier 1)
3. Zarate CA, Singh JB, Carlson PJ, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Archives of General Psychiatry. 2006. https://pubmed.ncbi.nlm.nih.gov/16894061/ (Tier 1)
4. Sanacora G, Frye MA, McDonald W, et al. A consensus statement on the use of ketamine in the treatment of mood disorders. JAMA Psychiatry. 2017. https://pubmed.ncbi.nlm.nih.gov/28249076/ (Tier 1)
5. U.S. Food and Drug Administration. Drugs@FDA: SPRAVATO (esketamine), NDA 211243, approval history. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=211243 (Tier 2)
6. U.S. Food and Drug Administration. SPRAVATO (esketamine) nasal spray prescribing information, revised January 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/211243s016lbl.pdf (Tier 2)
7. Arubuolawe OO, Folorunsho IL, Busari AK, et al. Combination of transcranial magnetic stimulation and ketamine in treatment-resistant depression: a systematic review. Cureus. 2024. https://pubmed.ncbi.nlm.nih.gov/39156335/ (Tier 1, small-study review)
8. 988 Suicide and Crisis Lifeline. https://988lifeline.org (Tier 2)

‍